Choosing the Right COVID-19 Vaccine: Inactivated or mRNA?

As the world continues to grapple with the ongoing COVID-19 pandemic, the choice of vaccine type comes into focus. Whether it’s the inactivated vaccine or the mRNA vaccine, both options are critical in the fight against the disease. In this article, we will explore the differences between these two types of vaccines, their effectiveness, and individual preferences in vaccine selection.

Understanding Inactivated and mRNA Vaccines

It is important to note that there is no coronavirus vaccine that contains inactivated coronavirus. Currently, the Janssen vaccine (Johnson Johnson) is an adenovirus vaccine. This type of vaccine uses a genetically modified version of a harmless virus to introduce the instructions for making the coronavirus spike protein. This induces an immune response without the risk of infection.

The mRNA vaccines, on the other hand, take a more direct approach. They contain mRNA (messenger RNA) that encodes the spike protein of the coronavirus. When injected, the mRNA enters cells and instructs them to produce the spike protein, which in turn triggers an immune response.

Comparing Inactivated and mRNA Vaccines

One of the key considerations when choosing between an inactivated vaccine and an mRNA vaccine is the number of doses required and their effectiveness. Some people prefer the Janssen vaccine because it requires only one dose, making it more convenient. However, studies have shown that the Janssen vaccine is somewhat less effective than the mRNA vaccines, especially in terms of preventing severe illness.

Based on the research and my personal experience, I opted for an mRNA vaccine for myself and my family. My experience with two shots of an mRNA vaccine (such as Pfizer or Moderna) was smooth, with no side effects to report. The effectiveness of mRNA vaccines is due to their precise targeting of the spike protein, which triggers a strong and durable immune response.

U.S. Vaccines and Recommendations

In the United States, there are currently three vaccines in use: Pfizer, Moderna, and Johnson Johnson. The CDC recommends any available vaccine, as all are highly effective in preventing severe illness, hospitalization, and death from COVID-19.

From a safety perspective, the mRNA vaccines are considered a safe and effective option, with fewer serious side effects compared to viral vector vaccines. Adverse events related to viral vector vaccines, such as the Janssen vaccine, have included rare but serious side effects like blood clots, which have raised concerns among healthcare providers and the public.

Personal Experience and Risk Considerations

As I approach the age of 67 and have a history of autoimmune disorders, I recognize the importance of being vaccinated to protect myself. Autoimmune diseases can weaken the body's natural defenses, increasing the risk of severe complications from COVID-19. Therefore, getting fully vaccinated is a critical step in mitigating these risks.

My second dose of the Pfizer vaccine, administered two days ago, was followed by no side effects, and I am in good health. The relief and safety that comes with being fully vaccinated, even if it means a mild case of the illness, are invaluable.

In conclusion, while both inactivated and mRNA vaccines play crucial roles in combating COVID-19, the mRNA vaccines are a strong choice due to their effectiveness and safety profile. It is essential to get vaccinated now to protect yourself and contribute to the collective safety of your community.